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
Blood Purification in Toxicology:Reviewing the Evidence and Providing Recommendations
Phenytoin
General Recommendation
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ECTR would be reasonable in selected cases of severe phenytoin poisoning (3D)
Indications
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ECTR is suggested if prolonged coma is present or expected (2D)
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ECTR would be reasonable if prolonged incapacitating ataxia is present or expected (3D)
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We recommend not to perform ECTR solely based on suspected dose of phenytoin ingested (1D)
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We recommend not to perform ECTR solely based on serum phenytoin concentration (1D)
Cessation of ECTR is indicated when
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Clinical improvement is apparent (1D)
Choice of ECTR
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Intermittent hemodialysis is the preferred ECTR in phenytoin poisoning (1D)
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Intermittent hemoperfusion is an acceptable alternative if intermittent hemodialysis is not available (1D)
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