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Blood Purification in Toxicology:Reviewing the Evidence and Providing Recommendations
methotrexate
(see full publication)
In patients with severe methotrexate poisoning receiving standard care treatments including folinic acid rescue therapy:
1) We suggest AGAINST performing extracorporeal treatments when glucarpidase is not administered (weak recommendation; very low-quality evidence)
2) We recommend AGAINST performing extracorporeal treatments when glucarpidase is administered (strong recommendation; very low-quality evidence)
3) We recommend AGAINST performing extracorporeal treatments instead of administering glucarpidase (strong recommendation; very low-quality evidence)
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